===== Vitamin B12 =====

  - aka cobalamin
  - important for cellular metabolism - DNA synthesis, methylation; mitochondria metabolism
  - classical pernicious anaemia with megaloblastic anemia uncommon
  - exact definition of deficiency contentious .. incidences 2.5 - 25%
  - vulnerable patient groups: vegan elderly female, pregnancy, gastric bypass with DM on metformin
  - classically treated with IM B12, oral 1g a day also works well
  - blood tests: B12, methylmalonic acid/ homocysteine
  - presents with hematological, neurological and psychiatric symptoms

====Questions====
 
  - How common is B12 deficiency in carpal tunnel syndrome/ patients with neurological symptoms?

===Meta===
  * Created 2020-11-29